The cause of the disease needs to be identified first and then treated according to the specific cause. Except for a few cases of benign congenital hyperbilirubinemia, which do not require treatment for the time being, most cases of hyperbilirubinemia caused by pathological factors require treatment in the hospital. Bilirubin is the main metabolite of iron porphyrin compounds in the body. The liver converts indirect bilirubin into direct bilirubin, which is excreted into the intestines through bile. Most causes of high bilirubin are due to poor bile excretion, but it may also be physiologically elevated. For a few benign congenital hyperbilirubinemia, such as Gilbert’s syndrome, if other tests are not abnormal, ensure reasonable nutritional intake can be relieved, can also use ursodeoxycholic acid, adenosylmethionine, gardenia jasminoides oral solution and so on for treatment. But bilirubin is high most of the pathological factors, need to go to the hospital to find out the cause of the disease, under the guidance of the specialist further clear diagnosis and treatment, so as not to delay the condition.