Quadruple therapy for Helicobacter pylori is usually taken without a sore throat. Quadruple therapy for Helicobacter pylori refers to the combination of four drugs, including a proton pump inhibitor (omeprazole, rabeprazole, etc.), a gastric mucosal protector/colloidal bismuth (bismuth potassium citrate), and two antibiotics (amoxicillin, clarithromycin, metronidazole, quinolones, tetracycline, and other optional two). Among the common adverse effects (>1%-3%) of the above drugs, the adverse effect of sore throat was not found. Normal administration of the drugs does not cause sore throat. Proton pump inhibitors and gastric mucosal protectants/colloidal bismuth can be taken 30 minutes to 1 hour before meals, and antibiotics can be taken after meals. If you are afraid of swallowing a large number of medications that may cause discomfort in the throat, you can swallow these medications tablet by tablet to relieve the discomfort. Specific medication use should follow the clinician’s instructions to avoid adverse events.