If a diabetic patient’s blood sugar control is not up to standard for a long time, it can cause diabetic nephropathy, and early unregulated treatment can cause uremia, with the following specific clinical manifestations: 1. renal anemia, the patient shows anemic appearance, severe anemia, and needs to be given erythropoietin and iron supplementation to correct the anemia. 2. renal hypertension, the patient often shows persistent hypertension, applying a variety of antihypertensive drugs for blood pressure control is not up to standard. 3. The patient’s hypoproteinemia can lead to sunken swelling of the lower extremities, ascites and pleural fluid, etc. 4. oliguria, the patient’s renal failure due to uremia, resulting in reduced urination, can appear oliguria, some patients can induce heart failure, hyperkalemia, etc. 5. acidosis, the patient’s failure to excrete acid, can lead to metabolic acidosis, can cause deep breathing. 6. 6. Hypocalcemia and hyperphosphatemia, patients with reduced hydroxylation of the kidneys, resulting in hypocalcemia with hyperphosphatemia, can develop secondary hyperparathyroidism in severe cases.