When leukemia is detected by fever after vaccination, leukemia should be treated promptly to slow down the progress of the disease. Common treatments include component blood transfusion therapy, drug therapy, hematopoietic stem cell transplantation and so on. Leukemia is mainly categorized into myeloid and lymphoid leukemia. According to the type of leukemia and your own condition, you should choose the appropriate treatment plan. 1. Component transfusion therapy: for severe anemia, oxygen absorption, transfusion of concentrated red blood cells and other treatments can be carried out; for bleeding caused by low platelets, single platelet suspension can be transfused. For patients with abnormal coagulation function, fibrinogen, plasminogen complex, plasma and other blood products can be infused to supplement the required coagulation factors for treatment. 2. Drug therapy (1) For acute lymphoblastic leukemia, drugs such as vincristine and cyclophosphamide can be used. (2) For acute myeloid leukemia of non-m3 type, patients can be treated with Zorubicin, Cytarabine, etc. For m3 type of leukemia, i.e., acute promyelocytic leukemia, retinoic acid and arsenic trioxide can be used in combination with induction and remission therapy. (3) Chronic granulocytic leukemia can be treated with molecularly targeted drugs such as imatinib and nilotinib, as well as interferon, leucovorin, and hydroxyurea. (4) Chronic lymphocytic leukemia can be treated with rituximab, glucocorticoids, fludarabine and cyclophosphamide. 3. Hematopoietic stem cell transplantation: for acute myeloid as well as lymphoid leukemia. In general, there is no definite relationship between vaccination and leukemia. At this time, if leukemia is detected, we should cooperate with doctors in time to choose appropriate medication plan. All of the above medications should be used under medical supervision.