GERD is a benign disease that generally does not affect the patient’s survival, but its complications such as upper gastrointestinal bleeding and esophageal cancer can be life-threatening. GERD is a disease in which the lumen of the gastroesophagus is overly exposed to gastric juices, causing damage to the esophageal mucosa and clinical GERD. The causes of GERD mainly include bacterial infection, chemical factors, etc. Heartburn and acid reflux are the main symptoms, which are obvious during fasting and at night, accompanied by pain in swallowing and difficulty in swallowing, etc. When there are serious complications such as upper gastrointestinal bleeding and esophageal cancer, it may affect the life. 1. Upper gastrointestinal bleeding: Gastroesophageal reflux disease (GERD) can cause upper gastrointestinal bleeding due to long duration and serious lesions, etc. If the amount of bleeding is relatively large, due to the lack of timely hemostasis and active resuscitation, the patient’s life may be endangered. 2. Esophageal stenosis: If reflux esophagitis is not treated in time and allowed to develop, it can cause esophageal stenosis, ulceration and perforation. And esophageal stenosis leads to difficulty in swallowing, which in turn causes dyspepsia and seriously affects the quality of life of patients. 3. Esophageal cancer: severe reflux esophagitis is malignant in nature and can cause esophageal cancer. If metastasis occurs, it may endanger the patient’s life and cause serious anemia, such as anemia caused by bleeding or iron deficiency anemia. GERD generally does not affect the patient’s survival, but its complications such as upper gastrointestinal bleeding, esophageal stricture, and esophageal cancer can be life-threatening. It is recommended that patients with GERD should be followed up in a timely manner in order to avoid delaying their condition.