Cranial repair is not only a protective layer for the soft tissues of the brain, but it is also an important guarantee to maintain the aesthetics of the head, and it is important to perform cranial repair as early as possible in the case of cranial defects. For cranial repair surgery, the material is the most important thing. A good material can not only improve the success rate of surgery. And it can reduce the chance of postoperative complications. There are titanium mesh and peek materials for skull repair, what is the difference between these two? As medicine advances, more and more cranial repair materials are becoming available for use. Plexiglass, light apatite and calcium phosphate bone cement materials, which were once used in clinical practice, have been gradually withdrawn from the medical scene due to their poor clinical results. Nowadays, the commonly used cranial bone repair material is titanium mesh, which is also a high-quality material that has been used for a long time with good results. However, the metal properties of titanium mesh often bring consequences such as sensitivity to hot and cold reactions and CT imaging errors to patients. Under the efforts of medical researchers, a new type of cranial bone repair material has been applied to clinical applications, that is, PEEK material. The scientific name of this material is polyether ether ketone, which is a kind of polymer biomaterials, in terms of elasticity, heat conduction, hardness, stability and other aspects of the human cranium is extremely close to the use of three-dimensional molding of the PEEK bone plate, can be a perfect fit with the skull structure, do not have to worry about the accuracy and aesthetics of the problem. Numerous clinical cases have shown that no discomfort has been found with PEEK cranial bone repair materials, so PEEK is a better choice for cranial bone repair. In terms of biocompatibility, PEEK is far superior to titanium mesh, and its modulus of elasticity, strength, insulation, and stability are all similar to that of autologous cranial bone. Using three-dimensional molding to produce the ancient plate, it can accurately match with the original cranial structure, which is the key to the success of the surgery. So we must understand clearly the choice of materials for cranial bone repair, cranial defect patients in the cranial bone repair needs to be determined according to the morbidity of the disease, regular hospitals will provide the right advice and guidance on the cranial bone repair materials for the sick.