Hypodense foci in the left lobe of the liver are generally considered as benign or malignant disease in the primary foci. First, malignant disease should be excluded, combined with the patient’s history of hepatitis, detection of methemoglobin, imaging, if it suggests that the patient has elevated methemoglobin and enhanced CT or MRI with post-enhancement enhancement on imaging, consider it as a primary tumor. If multiple lesions are suggestive of bull’s eye sign on imaging, consider metastatic lesions as malignant. Some patients show hypodense foci, considered as hepatic hemangioma, hepatic abscess, hepatic cyst, nodular hyperplasia, which need to be clearly diagnosed with the patient’s medical history or even puncture biopsy. Generally, relatively small benign lesions can be closely followed and observed, and surgery is considered when the lesions have a short-term significant increase or are not easily distinguishable from malignant lesions or have a tendency to become cancerous.