During the treatment of patients with moderate esophageal alloplastic hyperplasia on medication, the medication will not aggravate the progression of the disease, but it is possible that the medication may not be able to control the growth of the tumor. Moderate heterotrophic hyperplasia of esophagus is a benign lesion, which is a precancerous lesion due to atypical hyperplasia of esophageal mucosal glands. For some patients with active hyperplasia, it may become cancerous in a very short period of time, therefore, once diagnosed, it is necessary to give appropriate treatments in time to reduce the rate of cancerous lesions. Some patients with moderate heteroeuploidosis of the esophagus have overly active hyperplasia, which is poorly treated by medication alone, and the disease is likely to progress in the course of treatment, therefore, timely and minimally invasive surgical resection of the hyperplastic lesions is needed.