There is no “strongest” antipruritic drug, the cause of itchy skin may be ringworm, eczema, systemic diseases, etc., commonly used glycerine lotion, tretinoin cream, clotrimazole ointment and so on. 1. Ringworm: generally itchy skin caused by fungal infection, and can be accompanied by skin erythema, papules, scales, and personal hygiene habits, you can use antifungal drugs, such as clotrimazole ointment externally, and oral drugs such as itraconazole capsules. 2. Eczema: this is a common skin disease, and the etiology is very complex, commonly found in sensitive people, the skin can appear rash, itching, etc., can be used externally to stop itching agent such as glycerite lotion, zinc oxide ointment or use glucocorticoid cream such as tretinoin cream, oral antihistamine drugs such as loratadine. 3. Systemic diseases: when suffering from diabetes mellitus, uremia and other diseases, can also cause peripheral neuropathy itchy skin, need to actively treat the primary disease, to be controlled by the primary disease, the itchy symptoms can also be relieved. It is recommended to go to dermatology, endocrinology, nephrology and other departments for examination in a timely manner to avoid aggravating the condition, and do not believe in the so-called “local remedies” and “biased prescriptions”. Drugs should be used in accordance with medical advice.