Rivaroxaban belongs to anticoagulant drugs, during the use of certain hazards, serious cases will cause intracranial hemorrhage and other conditions, need to follow the doctor’s instructions for reasonable application. Rivaroxaban is commonly used to prevent the formation of venous thrombosis, through the inhibition of coagulation factors to achieve the effect of anticoagulation. However, the drug may cause angioedema, jaundice, hemorrhage and other adverse reactions in the course of use, among which hemorrhage is a more serious adverse reaction. The risk of bleeding with rivaroxaban may occur in severe cases, such as retroperitoneal hemorrhage, cerebral hemorrhage, subdural hemorrhage, and other systemic hemorrhages in multiple sites, so close monitoring is required during the use of the drug. Prompt medical attention is recommended for adverse reactions, and is contraindicated in patients with drug hypersensitivity and those with active bleeding.