The main treatment option for duodenal adenocarcinoma liver metastasis is surgical resection, besides, chemotherapy or radiotherapy can also be chosen. 1. Surgery: Surgery is the most important treatment plan for duodenal adenocarcinoma liver metastasis, and patients with smaller and fewer duodenal adenocarcinoma liver metastases have better prognosis after surgical resection of the lesions. 2. Chemotherapy, targeted therapy, etc.: after surgery and patients who cannot endure surgery can choose bevacizumab, oxaliplatin, irinotecan, capecitabine and other drugs according to their conditions. 3. Radiotherapy: radiotherapy can not only reduce the local symptoms of the tumor, but also play a curative role for a small number or isolated lesions. It is recommended to go to regular hospitals for comprehensive assessment of the condition and follow the doctor’s instructions to improve the prognosis and prolong the survival time of the patients, so as to avoid delaying the condition. Drug therapy has specific indications, dosage, and the possibility of adverse reactions, please strictly follow the doctor’s instructions, do not self-medication.