Bone closure playing growth hormone in general does not have much effect, improper use may also cause side effects. 1. Growth hormone: growth hormone has the effect of promoting bone growth, the target point of action is generally for the bone plate in the anterior chondrocytes, growth hormone can induce the anterior chondrocytes to differentiate into chondrocytes, so as to promote the longitudinal growth of the bone. If the bone has been closed, that is, the epiphysis has been closed, indicating that the cartilage has been completely ossified, at this time the use of growth hormone will not promote bone growth. 2. Side effects of growth hormone: growth hormone is regulated by the negative feedback system of hypothalamus-pituitary-serum growth hormone level, exogenous use of growth hormone needles will cause an increase in the level of serum growth hormone, and an increase in the level of serum growth hormone will inhibit the secretion function of the hypothalamus and pituitary gland. The pituitary gland, in addition to promoting the release of growth hormone, also releases thyroxine, which may lead to the side effect of central hypothyroidism. Growth hormone for bone closure should be administered in consultation with a clinician and should not be administered without authorization.