High total and direct bilirubin can cause jaundice, itchy skin, indigestion, abdominal pain and other symptoms. High total and direct bilirubin are mainly seen in bile duct stones, cholestasis syndrome, pancreatic head cancer and other diseases. In addition to the symptoms of abdominal pain and distension caused by the original disease, patients suffering from the above mentioned diseases may also suffer from the obstruction of bile excretion due to bile duct obstruction, and the direct bilirubin flowing back into the blood, which causes the levels of total bilirubin and direct bilirubin to increase, resulting in the yellowing of the eyes, skin, and urine color of the patients, accompanied by itching of the skin. If bilirubin collects in the liver for a long time, it will aggravate liver damage and cause indigestion and other symptoms. If not treated in time, it can lead to cirrhosis or even hepatocellular carcinoma as the condition progresses. If you find that total bilirubin and direct bilirubin are high, it is recommended that you consult a doctor as soon as possible, complete the relevant examinations to determine the cause of the disease, and seek treatment as soon as possible to avoid delaying your condition.