Sciatic nerve edema can be eliminated with medications such as mannitol and diosmin tablets, and treated with nerve-nourishing drugs such as methylcobalamin. When the sciatic nerve is compressed and damaged seriously, surgery should also be considered. When the sciatic nerve edema is in the acute stage, you can use some fast swelling drugs for treatment, such as mannitol, prednisolone and so on. After the acute stage, you can stop using the above drugs and use some milder drugs to reduce the swelling, such as Diosmin tablets, Mazolins, etc. As the sciatic nerve has been damaged, some nerve-nourishing drugs should be used for treatment, such as methylcobalamin, vitamin B1, etc. If the sciatic nerve is compressed or the damage is particularly serious, surgery should be considered to avoid serious complications. During the treatment period, we must follow the doctor’s guidance, safe and reasonable use of medication, and reasonable rest, avoid strenuous exercise.