Fever in the middle of the night can be treated by both physical cooling and medication. Physical therapy can be done by soaking a towel with warm water and wringing it out, repeatedly wiping various parts of the patient’s body, and then covering the forehead area with a fever-reducing patch, both of which can have a good physical cooling effect. If the patient’s body temperature exceeds 38.5 ℃, you can use antipyretic and analgesic drugs, such as ibuprofen suspension, compound acetaminophen tablets, lysamine, etc. These drugs have a relieving effect on the treatment of fever, headache, muscle aches and other adverse symptoms caused by cold and flu. Fever is a protective mechanism of the body after the occurrence of lesions, cooling treatment can only play a symptomatic role but not the root cause, so you need to go to the hospital as soon as possible to receive more detailed examination to identify the specific cause of the disease before symptomatic treatment.