With the spread of medical knowledge, many people have a new understanding of skull repair. Cranial repair is no longer a procedure that is considered to be rare. Every year, a large number of patients in our country require cranial repair surgery for a variety of reasons. For patients, they don’t care about discussing the cause of their condition, but more about whether the surgery will be successful, how much it will cost, and how long it will take to recover and be discharged. The key aspect of the surgery is the choice of materials. Patients have the right to choose either titanium mesh or PEEK material depending on their condition. There are significant differences between the two in terms of clinical outcomes and price. Titanium mesh is more widely and long-lastingly used, but postoperative discomfort, infection, and other maladies do occur. For the patient, this is no small toss-up. For the surgeon, repeated procedures increase the risk of medical treatment. Although PEEK has been used for a relatively short period of time, a large number of clinical facts have proven that PEEK, a material with high biocompatibility, low discomfort, complex shaping, perfect fit to the defect area, and excellent performance in a variety of ways, has not been found to have any rejection reactions in the time that PEEK has been used in cranial repair, and patients have recovered well. For patients concerned about the cost, this is actually a non-issue. The vast majority of the cost of skull repair surgery is in the materials. The larger the skull defect is, the more materials are used, and the price is naturally higher. Of course, patients with medical insurance or New Agricultural Cooperative can enjoy the corresponding medical insurance policy, and some medical expenses can be reimbursed. For families who are financially constrained, it can reduce a considerable burden.