Normal pregnant women with negative urine protein should pay attention when there is a plus sign. This situation is common in gestational hypertension disease, diabetes, kidney disease, etc., which can lead to urine protein plus, so be sure to check which piece of the problem. 1, gestational hypertension disease: mainly vascular endothelial damage, resulting in protein leakage, the formation of urine protein, due to the relatively large harm to the fetus and the mother, so be sure to pay attention to the need for hospitalization when necessary, timely termination of pregnancy, to reduce the appearance of adverse pregnancy outcomes. The patient should be hospitalized when necessary to reduce the occurrence of adverse pregnancy outcomes. 2. diabetes: pregnant women with urine protein is (+), should promptly adjust the glucose-lowering drugs and do relevant examinations for targeted treatment. 3. kidney disease: pregnant women with proteinuria (+), at this time, need to suspect whether the patient previously had kidney disease, but no previous examination led to no detection, and the pregnancy was found after the maternity examination. Excessive tests such as kidney biopsy should not be performed during pregnancy, and nephrology consultation is recommended if kidney disease is diagnosed. Patients need to have regular check of urine routine, urine protein quantification and kidney function, as well as close monitoring of blood pressure, usually pay attention to more rest and control diet to avoid excessive weight gain, most patients can have normal delivery.