1. Overview: Varicella-zoster virus infection causes a skin disease characterized by clusters of herpes and neuralgia distributed along the nerves, called herpes zoster. In young immune patients, it can be cured by antiviral and nerve nutrition treatments. In some elderly or immunocompromised patients, after the skin heals, the virus remains in the invaded nerve or even in the central nerve of the spinal cord. The pain can be aggravated by exertion and wind and cold. 2. Etiology: varicella-zoster virus invades the nerves and latent in the dorsal root ganglion of the spinal cord, and attacks when the immunity is low. 3, pathogenesis: varicella-zoster virus is latent in the dorsal root ganglion of the spinal cord after invading the nerve, and the virus can grow and multiply again when the body has low resistance or is tired, infected or cold, and move along the nerve fibers to the skin, causing intense inflammation of the invaded nerve and skin. If the pain persists without relief, it becomes postherpetic neuralgia. 4, Clinical manifestations: Herpes zoster occurs when the resistance of the organism is low, and the local skin heals after treatment, but the pain is not relieved, it is unilateral burning-like and discharge-like pain, and the pain can be aggravated by rubbing the skin with clothes. 5, complications: depression, accumulated optic nerve affecting vision, involvement of facial nerve facial palsy, etc. 6.Laboratory tests: blood routine, biochemical complete, four coagulation items, tumor marker test. 7.Other auxiliary examinations: chest X-ray, MRI of the spine. 8.Diagnosis: history of herpes, pain of neuralgic nature, physical examination reveals nociceptive hypersensitivity or nociceptive hypersensitivity along the nerve distribution. 9.Differential diagnosis: complex regional pain syndrome, neuritis, neuralgia caused by spinal tumor. 10.Treatment: general treatment methods include antiviral, nerve nutrition and analgesic treatment, such as acyclovir, adenosine cobalamin, carbamazepine, etc. Our department adopts comprehensive treatment, including intravenous PCA (patient-controlled analgesia) analgesia, ultrasound-guided nerve block, central interventional analgesic treatment and local sympathetic ganglion block, and trioxic macroautonomic therapy. 11. Prevention: When herpes zoster appears, promptly consult a regular hospital to avoid the formation of post-herpetic neuralgia, which causes long-term physical pain and economic stress. When traditional antiviral and nerve-nourishing treatment is ineffective, or when the herpes area is large and the pain level is severe, early neurointervention therapy is performed, and within one month neurointervention therapy combined with comprehensive treatment in our department can mostly cure. Herpes zoster is mostly caused by low resistance, so pay attention to rest and strengthen resistance during the disease, and if necessary, take immunity-enhancing drugs. In elderly patients with herpes zoster, the possibility of tumor increases, and screening can be performed if available. 12. Prognosis: Postherpetic neuralgia, also known as undead cancer, can be lifelong pain if not treated effectively. When the local skin of herpes zoster improves and is still painful, attention should be drawn to it and timely treatment.