1, SAPHO syndrome is currently recognized at home and abroad: SAPHO syndrome is an abbreviated acronym for synovitis (Synovitis), acne (Acne), pustulosis (Pusfu-losis), hypertrophy of bone (Hyperositosis), and osteitis (Osteitis), an autoimmune rare disease involving the skin and joints. The exact etiology is not clear, and the name of this disease was first proposed by Chamot et al. in 1987 [1]. There are few reports of this disease in China, which makes it highly susceptible to misdiagnosis and mismanagement. At present, SAPHO syndrome is mainly manifested by damage to the bones, joints and skin (clinical symptoms are mainly joint pain and skin acne, pustules, etc.), and imaging is the main method to determine bone damage. The whole-body bone scan can detect early bone damage, and its imaging manifests as abnormal foci of radioactive concentration in the anterior upper chest wall, and the typical image is the “bull’s head sign”. The sensitivity rate is about 88%. For the treatment of this disease, there is no special treatment plan internationally, mainly symptomatic supportive treatment, drug selection is similar to other immune system diseases, generally non-steroidal anti-inflammatory drugs as the first-line drugs, but the therapeutic effect varies from person to person (the patient in this case had increased chest pain after taking non-steroidal anti-inflammatory drugs), glucocorticoids and anti-rheumatic slow-acting drugs such as methotrexate, leflunomide, cyclophosphamide, etc. as second-line drugs. In recent years, biological agents such as TNF-a antagonists have been reported to be effective in the treatment of this disease, and bisphosphonates are also effective in relieving bone pain and can be used as third-line drugs. Because of the high recurrence rate after simple osteotomy, surgical treatment is not supported for the time being. 2, SAPHO syndrome Chinese medicine related discussion Chinese medicine for this disease is not clearly recorded, but with the available statistics, SAPHO syndrome in the treatment process, if the Chinese medicine intervention, the condition tends to stabilize, now reported in the literature, Chinese medicine treatment of this disease also has good efficacy. More and more studies have shown that TCM can be used as an alternative treatment for this disease, and new treatment methods are being explored. Due to the rarity of the disease, there are very few reports of TCM treatment, and the treatment plan of the disease varies among schools. In the treatment, according to the stage of the disease, Chai Hu Gui Zhi Tang is used to reconcile the cardinal organs, harmonize the Ying and Wei, and promote the flow of Qi and blood; Si Miao Wan and Ping Gastric San are used to clear the heat and dampness; Dou Wu Xie Sheng Tang is used to tonify the liver and kidney; Wang Yuan et al. Although SAPHO syndrome is a rare disease, the description of its main symptoms can also be seen in Chinese medicine, and can be treated with reference to “paralysis” and “impetigo”. Chinese medicine treatment should be based on a holistic approach, with reference to the theory of meridians, which is particularly effective. In this case, the distribution of the pustules and the painful joints are roughly in the way of the foot Shao Yin Kidney meridian, and the kidney is the main bone, so the treatment should focus on the kidney. Angelica sinensis warms and nourishes the blood, peach kernel and safflower invigorate the blood and laxative, boneset and mulberry nourish the liver and kidney, strengthen the waist and knees, white peony and licorice slow down the pain, and wei ling xian and geranium promote the benefit of the foot solar bladder meridian to help the kidney meridian. Although the patient did not take immunosuppressive drugs, he is old and physically weak, and his long illness has injured his vital energy, so he is easily attacked by poisonous evil and has signs of ligament blockage, so the formula was changed from safflower to chicken blood vine to enhance the function of activating blood and opening the ligaments, and added ground bark and white fresh peel to dispel wind and detoxification, so as to get rid of evil.