Prucalopride treats long-term persistent constipation by promoting gastrointestinal motility, but the specific efficacy varies from person to person, and the medication should be used in accordance with the doctor’s instructions. Procalcitonin is a gastrointestinal stimulant, which can enhance the peristaltic reflex and propulsive movement of the gastrointestinal tract through the activation of 5-hydroxytryptamine receptors, thus producing a therapeutic effect on long-term persistent constipation. Currently, this drug is mainly indicated for adult female patients with chronic constipation symptoms that are not adequately relieved with light laxatives. However, it should be noted that the therapeutic effect of Procalcitonin may be affected by individual’s physical condition, drug compliance and other factors, and it is more difficult to correct the long-term persistent constipation, so the specific efficacy of the treatment may have individual differences. In addition, this drug is contraindicated in people who are allergic to it or have renal dysfunction requiring dialysis, intestinal perforation or obstruction, etc. Adverse reactions such as headache and nausea may occur during the process of using the drug. Therefore, if long-term persistent constipation needs to be treated with Procalcitonin, it is necessary to use the drug under the guidance of a doctor and closely observe the efficacy of the drug and its reaction, and consult a doctor in time if any abnormality occurs.