In general, eat roxithromycin upset stomach should stop using the drug, symptomatic treatment. Roxithromycin belongs to the class of macrolide antibiotics, such drugs have a strong gastrointestinal stimulation, after eating roxithromycin upset stomach, may be the drug stimulation of the gastrointestinal tract caused by the adverse reaction, it is recommended to discontinue the use of roxithromycin, changed to other antibiotics alternative. Eating erythromycin stomach uncomfortable can take omeprazole, pantoprazole and other drugs to relieve gastrointestinal discomfort. Drink plenty of warm water, dietary attention easy to warm and soft and easy to digest, avoid eating some spicy stimulation as well as cold food. If the patient’s stomach has underlying diseases, such as chronic gastritis, peptic ulcer and other digestive diseases, the gastrointestinal tract is already very fragile, coupled with the stimulating effect of Roxithromycin, the stomach will be even more uncomfortable, therefore, need to be based on the examination of a clear basis of the treatment for the relevant diseases. Roxithromycin is a prescription drug, it is recommended to consult a doctor and take it as prescribed.