It is possible to use safflower oil after a sprain, but it should be used only after 48 hours after the injury. Because within 48 hours after the sprain, the soft tissue injury is in the bleeding period and has not yet coagulated to form a hematoma. The safflower oil belongs to the blood circulation and blood stasis class of drugs, the use of safflower oil at this time, may aggravate the bleeding, thus causing increased swelling of the sprained parts. Therefore, within 48 hours after the injury, it is recommended to use ice compress treatment, you can use ice towel, ice bag ice compress on the affected area, 20-30 minutes each time, 4-6 times a day, in order to promote local capillary constriction, reduce bleeding, thereby reducing swelling. 48 hours after the formation of local hematoma, and no bleeding, only then can use safflower oil to promote the absorption of hematoma.