Esophageal cancer, i.e. esophageal cancer, does not exist the statement of the best way to treat esophageal cancer in the late stage. The main symptoms of patients with esophageal cancer in the late stage are severe pain, difficulty in drinking water and so on. Patients can take systemic chemotherapy, targeted therapy, immunotherapy, radiotherapy, surgery and so on. 1. Systemic chemotherapy: patients with advanced stage of esophageal cancer will have severe pain, difficulty in drinking water, etc. If the situation permits, systemic chemotherapy can be carried out according to doctor’s instruction, with commonly used drugs such as fluorouracil, cisplatin, paclitaxel, etc., as well as pain relieving and nutritional supportive treatment. 2. Targeted therapy: Targeted therapy can be carried out under doctor’s guidance in advanced stage of esophageal cancer, and commonly used drugs include cetuximab, apatinib and so on. 3. Immunotherapy: patients with advanced esophageal cancer can be combined with immunotherapy according to relevant test results, and commonly used drugs include karelizumab, pembrolizumab, nabulizumab and so on. 4. Radiotherapy: radiotherapy is one of the important modes of comprehensive treatment for esophageal cancer, which mainly includes preoperative, postoperative and radical radiotherapy. For patients with advanced stage of esophageal cancer, palliative radiotherapy can be given according to the situation to control the disease and improve the prognosis. 5. Surgical treatment: for patients with advanced esophageal cancer, if patients have obstruction symptoms. Endoscopic dilatation, intra-esophageal stent placement, gastrostomy and other surgical methods can be adopted. There is no best treatment method for patients with advanced esophageal cancer, patients should consult doctor in time and follow doctor’s prescription to avoid blind medication.