Epilepsy is a chronic disease and is prone to persistent seizures. First of all, the patient should be flattened to prevent falling from the bed. Immediately loosen the collar button and trouser belt for the patient, turn the patient’s head to the side to facilitate the outflow of oral secretions, and prevent asphyxia caused by accidental inhalation. If there is too much secretion from the mouth and nose, it should be sucked up immediately. To ensure a smooth airway, an oropharyngeal ventilation tube can be placed to give oxygen. In the tonic phase, the patient’s teeth are tightly closed due to general muscle contraction. Secondly, the patient should be fixed with sheets and clothes during the clonic phase to protect the patient from muscle tears due to muscle spasm. Observe vital signs closely and monitor pupils, respiration, blood pressure, pulse and body temperature regularly. To correct hypoxia, tracheal intubation and appropriate assisted ventilation should be given decisively, and tracheotomy should be performed when necessary. A rapid-acting, adequate, intravenous regimen with few adverse effects should be used to control status epilepticus and terminate seizures promptly. (Clonidine, 1-4 mg intravenously, can be effective within a few minutes and should be noted for its stronger respiratory depressant effect than Valium. Valium 20 mg IV once is more effective in controlling seizures.) Give broad-spectrum antibiotics to prevent infection, reduce cerebral edema with 20% mannitol sedation, counteract hyperthermia with physical cooling, correct electrolyte disturbance and pay attention to acid-base balance. Finally, while controlling seizures, perform necessary physical and laboratory examinations, including brief neurological signs and fundus, blood glucose, electrolytes, urine, arterial blood gas analysis, electrocardiogram and electroencephalogram, etc. Blood pressure must be monitored, and in case of low blood pressure, dopamine may be applied for maintenance. For the treatment of persistent epilepsy, if the seizure cannot be terminated even in the initial and additional cases, anesthesia (such as thiopental sodium, etc.) should be applied with the support of tracheal intubation and assisted ventilation to terminate the status epilepticus. Warm tip: Patients with epilepsy with persistent seizures must not panic, follow what is said above, it will control the condition.