The prevention and care of DVT in clinical practice refers to the prevention and care of lower extremity deep vein thrombosis. There are many high-risk factors that cause patients to develop lower extremity DVT, such as surgery, trauma, tumor, and pregnancy. If the patients belong to the high-risk group of DVT formation, they need to give active protective measures, for example, they can use anticoagulant drugs beforehand. The commonly used anticoagulant drugs in clinical practice are low-molecular heparin sodium, which can be used once a day, one for each time, for subcutaneous injection, which can well prevent the formation of lower limb DVT. In addition, patients can also massage, get out of bed more often and use air pressure massager to massage the lower limbs, which can also play a good role in preventing the formation of lower limb deep vein thrombosis. Once the patient develops lower limb deep vein thrombosis, active anticoagulation and thrombolytic therapy need to be given for the patient to recover well.