The statement that cirrhotic nodules will become cancerous with the new crown vaccine is wrong and has no scientific basis. Cirrhotic nodules are generally some regenerative nodules surrounded by fibrous tissues in the liver on the basis of diffuse cirrhotic lesions, and these regenerative nodules can continue to grow and enlarge, and some large nodules may become cancerous. Factors leading to the development of cancerous cirrhotic nodules include viral infection, genetic factors, environmental factors, dietary factors and so on. Cirrhotic nodule patients can stimulate the body to produce antibodies to resist the invasion and infection of the new coronavirus after injection of the new coronavirus vaccine, which can play a protective role for the patients, and there is no research data confirming that the new coronavirus vaccine can lead to cirrhotic nodule cancer.