The cure rate of IgA nephropathy grade III is very low, and it is generally difficult to cure, but there are large individual differences among patients, so it is impossible to generalize, the purpose of treatment is to slow down the progression of the disease, and if it is well controlled, the 10-year survival rate is about 80%~85%. The pathology of IgA nephropathy grade 3 is mainly characterized by diffuse glomerular proliferation of mesangial cells and widening of the mesangial stroma, occasional crescents, some interstitial edema and tubular atrophy. Symptoms of IgA nephropathy are painless hematuria, some of them may have high blood pressure, and tertiary is usually accompanied by different degrees of renal function impairment, so it is more difficult to cure, if controlled in time, the renal survival rate of 10 years is 80%~85%, and that of 20 years is 65%, but some of them may also develop rapidly into end-stage renal disease, or even death. IgA nephropathy has an insidious onset and is mostly diagnosed by examination when hematuria is detected. It is recommended that patients should consult hospitals in time when they have uncomfortable symptoms, identify the causes and follow the doctor’s instructions for treatment in order to avoid delaying the condition.