Cholangiocarcinoma that cannot be treated by surgical resection indicates that the condition is serious and is mainly treated with palliative care. The main purpose of palliative care is to relieve the current symptoms of patients and improve their quality of life in later stages. Common palliative treatments for cancer include radiotherapy and palliative surgery. Palliative surgery is a modality that can significantly relieve the patient’s symptoms, including percutaneous hepatic puncture for biliary drainage (PTCD) or placement of an endoprosthesis and gastrojejunostomy. The former is endoscopic nasobiliary drainage or placement of an endoprosthesis with the aim of draining bile and reducing jaundice. In addition to this, Longmire procedure, Roux-er anastomosis can also be performed. Gastrojejunostomy is mainly used for digestive tract obstruction caused by tumor invasion or compression of duodenum, and gastrojejunostomy is feasible to restore the smoothness of digestive tract and improve the quality of patient’s survival. Cholangiocarcinoma itself is not sensitive to radiotherapy and has limited therapeutic effect. It is suggested that bile duct cancer patients should go to large-scale regular hospitals for consultation and actively cooperate with the treatment under the guidance of professional doctors.