Patients with coronary artery disease may have symptoms of ankle swelling. Coronary artery disease patients is the emergence of coronary artery stenosis, coronary artery stenosis will lead to insufficient blood supply to the myocardium, the patient mostly manifested as angina symptoms. Some patients with angina pectoris, due to insufficient blood supply to the myocardium will have a decline in cardiac function, heart failure can occur, can be manifested as symptoms of ankle edema. Cardiac insufficiency increases venous return pressure and blood stasis in the lower extremities, increasing venous pressure, which can manifest as edema in the ankle area. Patients may also experience chest tightness, and medications to reduce cardiac load, such as furosemide and hydrochlorothiazide, should be given if necessary. Coronary artery disease patients with ankle edema, should promptly go to the hospital, under the guidance of the physician to clarify whether the existence of cardiac insufficiency, if necessary, comply with medical advice can be treated.