There is no such thing as the best solution for knee joint pain clinically. For knee joint pain there are gout, synovitis, osteoarthritis, rheumatoid arthritis, according to the cause of the disease to take medication, physical therapy or surgical treatment. 1. Gout: usually reduce the intake of purine food, application of uric acid-lowering drugs such as allopurinol or febuxostat, local topical diclofenac diethylamide emulsion. 2. Synovitis: apply non-steroidal anti-inflammatory drugs, such as diclofenac sodium delayed-release tablets or nimesulide dispersible tablets, local ultrashort-wave physiotherapy to improve circulation and promote fluid absorption. 3. Osteoarthritis: joint injection of sodium vitrate, oral glucosamine sulfate capsule, oral pain medication, such as sodium aceclofenac, magnetic therapy, ultrasound physiotherapy. Conservative treatment is ineffective to perform joint replacement surgery. 4. Rheumatoid arthritis: applying anti-rheumatic drugs such as POTASONE or Leflunomide. Local injection of glucocorticoids, the application of traditional Chinese medicine hot ammo packs or thunder fire moxibustion treatment. Knee pain to go to the hospital to find out the specific causes, but also need to rule out meniscus injuries and knee tumors and other diseases caused by knee joint pain, for the cause to choose the best solution.