Frequent thigh muscle throbbing may be caused by physiological factors such as overexertion, or it may be caused by motor neuron disease, hyperthyroidism, electrolyte disorders and other pathologic diseases. 1. Overexertion: such as extreme anxiety and tension or overexertion can cause muscle spasm, causing frequent thigh muscle throbbing. 2. Motor neuron disease: due to infection, immunity and other factors leading to degenerative changes in motor neurons, frequent thigh muscle throbbing can occur. 3. Hyperthyroidism: due to increased muscle stimulation caused by hyperthyroidism, frequent thigh muscle throbbing can occur. 4. Electrolyte disorders: Electrolyte disorders such as calcium deficiency can lead to increased excitability of the nervous system, causing frequent muscle contractions and spasms, which can lead to frequent thigh muscle throbbing. Frequent thigh muscle throbbing may also have other reasons, if the persistence of non-relief or accompanied by other symptoms, it is recommended to go to the hospital in a timely manner to improve the examination to determine the cause of the disease, and then follow the doctor’s instructions to give targeted treatment or treatment, so as to avoid delaying the condition.