Upper Fire and Lower Cold is a phenomenon in which there is fire in the upper burner and cold in the lower burner, which is known as the Cold-Heat Mismatch Certificate in Chinese medicine. It can be treated by Jiaotai Pill and Wu Mei Pill. 1.Jiaotai Pill: composed of Huanglian and Cinnamomum cassia, Huanglian clears the fire of heart, Cinnamomum cassia warms the kidney and helps yang (warming and tonifying yang qi of the kidney). The main treatment for heart-kidney disharmony (heart fire, kidney yin deficiency, heart and kidney physiological dysfunction), symptoms such as palpitations (rapid heartbeat, often accompanied by panic), insomnia and so on. 2. Umei Pill: composed of Umei, Cinnamon, Cinnamomum Cassia, Rhizoma Polygonati Odorati, Radix et Rhizoma Cyperi, Radix Angelicae Sinensis, Radix et Rhizoma Ginseng, Radix et Rhizoma Ginseng, Radix et Rhizoma Polygonati Odorati, and so on, which has the effect of cleansing the upper and warming the lower. Among them, epiphyllum, cinnamon stick and dry ginger have the effect of warming and tonifying, while Huanglian and Huangbai have the effect of clearing heat. This formula can be used in treating the syndrome of upper fire and lower cold. The adverse effects of the above formula have not been clarified. If manifestation of upper fire and lower cold occurs, clinicians should be consulted and treatment should be in accordance with medical advice.