Medications to shrink the prostate include finasteride, tamsulosin, ofloxacin, bicalutamide, and goserelin, each of which can be used to treat different causes of increased prostate size. Finasteride is a 5α-reductase inhibitor, finasteride inhibits prostate enlargement by lowering the level of dihydrotestosterone in the blood and prostate tissues, tamsulosin is a selective α1-adrenergic receptor blocker, with the effect of relaxing the smooth muscle of the prostate, and they are used in the treatment of enlarged prostate caused by benign prostatic hyperplasia. Bicalutamide is a nonsteroidal antiandrogen drug that causes prostate tumors to shrink by inhibiting androgen stimulation of the prostate, and goserelin is a gonadotropin-releasing hormone analog that inhibits gonadotropin secretion, and they are used in the treatment of prostate enlargement due to prostate cancer. Ofloxacin is a broad-spectrum antimicrobial drug of the quinolone class, and it can be used in the treatment of prostate enlargement due to prostatitis. If you need to use medication to reduce the size of the prostate, it is recommended that you first visit a hospital to identify the cause and follow your doctor’s instructions.