Cholera is a class A infectious disease caused by bacterial infection. Cholera is usually caused by cholera enterotoxin group O1 or O139 Vibrio cholerae infection, which belongs to a kind of infectious disease of category A. It often occurs in coastal areas in summer and fall seasons in China, and the incidence of the population is mainly in adults, and the bacteria usually comes from contaminated water, seafood, fruits and so on, and the cholera patients as well as those who carry the bacteria of cholera are the main sources of infectious diseases. Usually the incubation period of cholera is 1~3 days, and the onset of the disease is relatively rapid, patients mainly manifest diarrhea, vomiting, and may be accompanied by muscle cramps, shock and other serious conditions. Cholera should be treated immediately after discovery, and should be strictly isolated, timely replenishment of body fluids and antidiarrheal treatment, can use levofloxacin capsule, compound flavin tablets, montelukast and so on. Daily to maintain dietary hygiene, pay more attention to rest, a avoid close contact with cholera patients.