Total bile acids are mainly the metabolites of cholesterol decomposition and metabolism in the liver and enterohepatic circulation, and are the final metabolites of cholesterol in the body, so total bile acids can reflect the process of cholesterol absorption, decomposition and metabolism in the body. High total bile acids are usually seen in the following conditions: 1. in diseases of the liver, such as acute and chronic hepatitis, primary biliary cirrhosis, and malignant tumors of the liver, etc. 2. in lesions of the bile ducts and biliary system inside and outside the liver, such as intrahepatic bile duct stones, extrahepatic bile duct stones, cholecystitis, and malignant tumors of the biliary system, etc. These conditions can also lead to high total bile acids.