Blisters in foot calluses can be treated by sterilizing the affected area by applying medications such as alcohol or erythromycin ointment and picking it with a sterilized needle. The formation of foot calluses is mostly due to keratosis pilaris skin damage caused by pressure or friction on the feet. For the organism appeared in the foot callus blisters phenomenon, it can be applied through the application of alcohol or erythromycin ointment and other drugs to the affected area disinfection, and the use of sterilized needles for picking treatment or into the hospital to use sterile syringes, the blisters in the liquid drawn out of the body. At the same time, gauze bandages can be used to prevent the blisters from becoming infected or inflamed. If these symptoms are accompanied by significant pain, it is recommended that you seek medical attention to prevent the blister from growing larger and becoming infected.