There are no reports of gene therapy for the treatment of COPD. The treatment of COPD needs to be based on the stage, with medication and non-pharmacological treatment in the stable stage, and medication and respiratory support in the acute exacerbation stage, and the medication should be taken in accordance with the doctor’s prescription. Gene therapy refers to the introduction of exogenous normal genes into target cells to treat diseases caused by genetic defects or abnormalities. It is commonly used to treat certain gene-related diseases, such as thalassemia and neurodegenerative diseases. There is no literature to support that gene therapy can treat COPD. Patients with chronic obstructive pulmonary disease should follow the doctor’s instructions for standardized treatment. During the stabilization period, medication can be combined with non-pharmacological treatments, such as respiratory rehabilitation, oxygen therapy, and non-invasive mechanical ventilation. Commonly used medications for patients with chronic obstructive pulmonary disease include bronchodilators, such as beta2 agonists (salbutamol), cholinergic receptor blockers (tiotropium bromide), and inhaled glucocorticoids (budesonide). When chronic obstructive pulmonary disease occurs, you need to receive regular treatment, not blind treatment.