Skin ulceration with imiquimod cream is caused by overstimulation of the skin with imiquimod cream. It is necessary to stop using the drug in time, and if necessary, can be treated by life conditioning or other medications. 1. Stop using the drug: a few patients may appear local skin surface defects or ulceration, or even necrotic tissue. You need to stop using the drug in time, usually after stopping the drug, it will be scabbed, with the shedding of the scab body, the area will return to normal. 2. Life management: recently, we need to pay attention to avoid the part of the sewage or be polluted by dirt, so as to avoid secondary infection, if there is itching, avoid scratching the affected area. 3. Medication: If the area is infected, erythromycin ointment or petroleum jelly gauze can be used as prescribed by the doctor to protect the treatment and relieve the symptoms of infection. It is recommended that patients consult a doctor in a timely manner, strictly follow the doctor’s instructions to regulate the treatment, and avoid self-medication.