Azithromycin because of the long half-life, eat 5 days can be discontinued for 4 days, during the discontinuation of the body is still effective drug concentration, can also reduce gastrointestinal reactions. The following answers are based on the pharmacokinetics, pharmacodynamics, adverse effects and bacterial resistance characteristics of azithromycin. Because azithromycin is widely distributed in tissues, slow metabolism, metabolic half-life of up to 68 hours; after discontinuing azithromycin, its blood concentration can be maintained in the effective range, the bacteria can still be in the state of inhibited growth. Azithromycin’s gastrointestinal reaction and the time of use of the drug is positively correlated with the continuous application of the greater the chance of discomfort; and continuous use of the drug is prone to drug-resistant phenomenon, so clinically depending on the severity of the disease, choose 3 to 7 days as a course of treatment, 4 days after the continuation of the second course of treatment. Azithromycin should be used according to the instructions and under the guidance of a doctor, if discomfort occurs, please consult a doctor in time to avoid serious consequences.