Severe diarrhea without ascites in advanced stage of liver cancer may be caused by poor digestion, hypoproteinemia, enteritis, drug-induced diarrhea and so on. 1. Poor digestion: patients with advanced stage of liver cancer will suffer from poor digestion, which will lead to food not being thoroughly digested and then irritate the intestines, which will lead to diarrhea. 2. Hypoproteinemia: patients with advanced stage of liver cancer will have hypoproteinemia, which will lead to intestinal infection and lead to diarrhea. 3. Enteritis: advanced stage of liver cancer is easy to be combined with intestinal infection, and the inflammation of intestines will lead to abnormal peristalsis of intestines, which will lead to increased frequency of stools and even diarrhea. 4. Pharmacological diarrhea: targeted drugs can also cause diarrhea, which is mostly due to the stimulation of intestinal tract by drugs, causing intestinal hyperfunction. Diarrhea without ascites in advanced stage of liver cancer may also be caused by other reasons, such as intestinal edema, intestinal flora imbalance and so on, which need to seek medical treatment in time to avoid delaying the condition.