Long-term use of corkscrew on the body’s effects mainly include dependence, habitual constipation, mucosal damage. 1. Produce dependence: the principle of Keserol is the use of glycerin or sorbitol hypertonic effect, so that the stool softening, at the same time can stimulate intestinal, promote defecation. Short-term use of efficacy is relatively good, and there is no obvious side effects. However, if the patient long-term use of Kepleria, it will lead to a decrease in the sensitivity of the rectal wall to the drug, and produce a sense of dependence, even if the use of Kepleria will not stimulate defecation. 2. Habitual constipation: there is glycerin in Keselu, glycerin will absorb the water in the intestine, long-term use may make the intestinal wall dry, causing habitual constipation. 3. Mucosal damage: if long-term use of Keselu, will damage the mucous membrane of the anus, will increase the intestinal mucous membrane abrasion or the chance of infection. Therefore, corkscrew can not be used regularly to avoid unnecessary effects on the body. The use of Kai Sei Nou needs to follow the doctor’s instructions, and if necessary, you need to go to a regular hospital, the doctor examined for standardized treatment.