Children’s retroperitoneal lymph nodes are usually caused by bacterial infection, viral infection, tuberculosis infection, etc. The causes are different and so are the treatment modalities, so it is recommended to consult a doctor in time to find out the cause of the disease and then treat the symptoms. 1. Bacterial infection: Bacterial infection causing retroperitoneal lymphadenitis can be treated with oral antibiotics or intravenous fluids under the guidance of a doctor. Penicillin, erythromycin, cephalosporin and other drugs can be used for treatment. 2. Viral infections: Most viral infections cause retroperitoneal lymphadenitis that is self-limiting and requires no special intervention. It can be treated with anti-inflammatory and analgesic drugs such as ibuprofen or glucocorticoids such as dexamethasone for specific symptoms. 3. Mycobacterium tuberculosis infection: Retroperitoneal lymphadenitis caused by mycobacterium tuberculosis infection needs to be treated with anti-tuberculosis drugs, which can be isoniazid, streptomycin, rifampicin and other drugs under the guidance of the doctor. Children with retroperitoneal lymphadenitis usually need surgery if conservative treatment is ineffective. In addition, it should be noted that during the treatment period, the diet should be light, avoid spicy, greasy and other stimulating food. All of the above medications should be used under the guidance of a doctor, avoid self-medication.