Whether low eGFR is important or not is related to the cause of low glomerular filtration rate. If the low glomerular filtration rate is caused by acute kidney injury, after correcting the reversible factors, the renal function can be gradually recovered, and it may not be important at this time; if the low glomerular filtration rate is caused by chronic renal insufficiency, with the progression of the disease, it may develop into uremia, and it is more serious at this time. Renal function eGFR is the estimated glomerular filtration rate, which is usually calculated by various formulas in clinic by applying various laboratory data, such as urea, creatinine, cystatin C, etc., combined with patient’s gender, age, ethnicity and other information. When the glomerular filtration rate is low, it usually indicates that the glomerular filtration function has decreased, suggesting that the patient’s kidney function is impaired. If acute kidney injury leads to low glomerular filtration rate, such as diarrhea, obstruction, etc., when rehydration, relief of obstruction and other reversible factors are corrected, renal function may gradually recover, and at this time, it may not matter; if chronic renal insufficiency leads to low glomerular filtration rate, such as glomerulonephritis, diabetic nephropathy, etc., with the progress of the disease, it may develop into uremia, and at this time, it is more serious. If patients find that the glomerular filtration rate is low, it is recommended to go to the regular hospital in time, improve the examination to clarify the cause of the disease, and then give targeted treatment or treatment under the guidance of the doctor.