Monkeypox at present there is no specific therapeutic drugs and methods, the treatment is mainly based on symptomatic supportive therapy, supplemented by general treatment. 1. Symptomatic treatment: (1) cooling: physical cooling is often used warm water or low concentration of ethanol for whole body rubbing, generally rubbing 5 minutes to 10 minutes, or use with ice packs, ice cap cold compresses on the head. (2) sedation: the emergence of irritability can be given a small amount of sedatives such as isoprinosine and so on. (3) antipruritic disinfection: the itching is obvious to give 1:4000 potassium permanganate solution or sodium bicarbonate solution for wet compresses on the rash. 2. General treatment: once the diagnosis is confirmed, it is necessary to go to a specialized infectious disease hospital for isolation treatment. Patients with this disease should rest fully and avoid strenuous activities. If the condition is serious, patients who cannot drink water can be rehydrated through vein, and patients who cannot eat can be supplemented with nutrients through vein. If you feel sick, you need to go to the hospital as soon as possible, and the doctor will formulate individualized treatment plan according to the specific condition, so as not to delay the condition.