Levofloxacin and doxycycline are both antibiotics, their indications are different, can not be separated from the indications to evaluate which one is more effective, the specific use of drugs need to be in the regular hospital under the guidance of a professional doctor. Levofloxacin is a quinolone antibiotic with broad-spectrum antibacterial effect, it has strong antibacterial activity against most enterobacteria, such as Escherichia coli, Proteus spp. and Klebsiella spp. and other gram-negative bacteria, and also has some antibacterial effect against gram-positive bacteria such as glucose globococcus and Streptococcus pneumoniae, but it has a poor effect on anaerobic bacteria and enterococci. Levofloxacin may cause adverse reactions such as gastrointestinal reactions, hepatotoxicity and nephrotoxicity, and should be used under the guidance of a medical professional. Doxycycline is a tetracyclic antibiotic with strong antibacterial activity against Staphylococcus aureus and Streptococcus pneumoniae, etc. It also has a certain degree of antibacterial effect against Mycoplasma, Chlamydia and Actinomyces. Doxycycline may cause enamel and bone dysplasia and is contraindicated in children under eight years of age, pregnant women and nursing mothers. Both can be used to treat infectious diseases, but should be used in accordance with the indications, and the actual antibiotic to be used should be judged by a medical professional.