Whether a ground glass nodule in the lung is tuberculosis requires dynamic observation combined with a CT examination of the chest to make a comprehensive determination. Ground glass nodules in the apical, posterior, and dorsal segments of the lower lobe of the lung need to be differentiated from tuberculosis. PPD test, T-cell test for TB infection, and sputum check for antacid bacilli can be done clinically. This is then combined with whether the patient has symptoms of cough, coughing sputum, hot flashes, night sweats, blood in sputum and physical wasting, and whether there is a history of contact with TB patients to get a comprehensive picture of whether the patient may have early TB. In case of early TB there may be polymorphic changes including plaques, exudates, proliferation, nodules, calcifications, cavity formation and pleural thickening. In conclusion, isolated ground glass nodules are relatively unlikely to be tuberculosis. In the case of pulmonary ground glass nodules with polymorphic changes, further clarification is needed to determine whether the nodule is early-stage tuberculosis.