High alkaline phosphatase after having gallstone surgery is mostly due to post-surgical biliary inflammation and residual stones in the common bile duct. Alkaline phosphatase is an enzyme widely distributed in human tissues such as liver, bone, intestine and kidney. Most gallstone surgeries are minimally invasive cholecystectomies performed laparoscopically. Biliary tract injury during surgery can cause postoperative biliary tract inflammation, leading to elevated values caused by blocked excretion of alkaline phosphatase. In a small number of patients, residual stones in the common bile duct after surgery can cause biliary obstruction, which can also lead to elevated alkaline phosphatase values. After the gallstone surgery should pay attention to avoid overeating, fried, greasy food, avoid drinking alcohol, found that the alkaline phosphatase is elevated should be actively standardized treatment.