The medical community has become increasingly interested in adipose tissue grafting because of its regenerative capacity. Several studies have demonstrated the role of grafted fat in repairing skin properties, such as improving skin texture and increasing skin elasticity. Fat grafting techniques are now widely used in plastic surgery, mainly to address the problem of facial aging. In addition to facial aging in Caucasians, aging of the hands is hard to ignore. In Western countries, fat grafting techniques are also widely used to improve the aging of the fingers. The deep structures of the face and skin continue to deteriorate with increasing age. This aging process is the result of environmental factors to which the original skin was subjected, especially exposure to ultraviolet light. Skin aging is understood histologically through: fibrous degradation of the extracellular matrix (including acid-resistant elastin fibers and collagen types I, III, and IV) and loss of oligosaccharides, lesions that impair the dermis’ ability to retain water; additionally, in aging skin, the decrease in the number of fibroblasts and, in particular, the disruption of the distribution pattern of the original abundance of elastin fibers in the reticular dermis, leading to a Loss of skin elasticity and tension; in the deeper tissues of the skin, tissue atrophy can be observed, causing loss of facial contour and angularity. There are two main cell groups present in adipose tissue, mature adipocytes and the vascular stromal fraction. The vascular stromal fraction is a mixed group of cell populations that contain a certain number of adipose-derived MSCs. The high self-renewal and in vitro expansion potential of adipose-derived MSCs, as well as their ability to differentiate into a wide range of cell lineages, make them important in regenerative medicine. MSCs also have important paracrine roles, stimulate angiogenesis, are antioxidants and modulate immune tolerance and inflammatory responses. The use of adipose-derived stem cells in clinical studies (e.g., radiation dermatitis, posterior burns, scleroderma, post-traumatic stress disorder) has also yielded satisfactory results. These potential mesenchymal stem cells, which are found in the vascular stroma portion of adipose tissue, can be obtained by a simple extraction method. The next step is to visualize the magic of stem cell therapy through pictures. After two treatments, elastic fibers increased significantly, stained black and localized in the superficial dermis. Significant neovascularization at the dermal-subcutaneous tissue junction after both treatments. In the dermis, both treatments affected the deformation of the collagen and reticular fiber network. Before treatment, large-diameter elastic fibers were characterized by patchy “leopard spots,” as well as collagen formation in the form of reticulations and bands. After treatment, the area of the extracellular matrix was enlarged. Immunohistochemistry showed a certain amount of increase in both procellulose and elastinogen. To summarize, the skin treated with autologous lipid components and vascular matrix fractions, the skin showed a reduction of the elastic fiber network and the appearance of new acid-resistant elastic fibers in the papillary dermis. Ultrastructural examination revealed alterations in the three-dimensional structure of the reticular dermis and the presence of richer microvascular beds. Similar results were seen after MSC treatment. This evidence suggests that both the treatment of the fatty and vascular matrix portion of the dermis and the MSC treatment improve the structure of the collagen and elastic fibers of the dermis to achieve rejuvenation, and are an effective way to perform facial rejuvenation procedures!