Small hands and feet are mostly related to genetic factors, but it is important to exclude specific diseases, such as growth hormone deficiency, prader-willi syndrome, etc., which can present with small hands and feet. If it is a genetic factor, there is no good way to change the genes of small hands and feet in the family who have small hands and feet. If there is growth hormone synthesis or secretion disorder during the developmental period, it can affect the growth of the bones in the hands and feet, which will lead to small hands and feet. Growth hormone level measurement and MRI of the head can determine whether there is a growth hormone secretion insufficiency before adulthood, and the lack of growth hormone during the developmental period can be injected with growth hormone treatment. If the epiphyses of the hands and feet are already closed, it is difficult to improve the thinness of the hands and feet. Malnutrition during the developmental period can lead to the small size of the hands and feet, and malnutrition is often accompanied by the developmental deficiencies of other organs.