The efficacy of glucocorticoids (hereafter referred to as hormones) in the treatment of rheumatoid arthritis makes people desire them, but their side effects also make people fear them. So how should hormones be applied in the treatment of rheumatoid arthritis? After years of repeated clinical verification, experts have basically big city consensus that there are two major misconceptions about hormones in the treatment of rheumatoid arthritis. 1, is the indiscriminate use of hormones because of the strong anti-inflammatory effect, can quickly and effectively relieve the symptoms of rheumatoid arthritis, the 40s glucocorticoids were introduced in the early days, is considered to be the treatment of RA ‘miracle drug’. Many patients applied for a long time, and the symptoms were indeed better controlled at the beginning, but the reason was that hormones could only reduce the symptoms, not relieve the disease, and after many years patients not only had serious joint deformities, but also had other side effects of hormones, such as hypertension, diabetes, osteoporosis, etc. 2, not used, because people found out that hormones can not stop joint deformation, and have many side effects, and dependence, the enthusiasm of using hormones soon decreased, and even in the 70-80s many people firmly opposed to treat RA with hormones. so that some severe rheumatoid arthritis disease can not be well controlled. Most scholars now believe that hormones are not the drug of choice for the treatment of rheumatoid arthritis, and most patients do not need to be treated with hormones. However, in some patients with significant joint swelling and pain, ineffective NSAIDs, and slow onset of DMARDs, a combination of low-dose steroid corticosteroids (prednisone 10-20 mg/day) is used until the disease-modifying drugs take effect, as proposed in the next-step treatment protocol. Recent studies have also suggested that low doses of steroid corticosteroids may delay bone destruction in RA joints. It has even been suggested that some patients with severe rheumatoid arthritis may be given intravenous hormone shocks (methylprednisolone 200-500 mg/day for 3 days). When the joint swelling and pain are basically relieved and the DMARDs start to take effect, the hormone is gradually reduced to stop. In this way, the strong anti-inflammatory effect of hormones is brought into play, and the side effects caused by long-term hormone application are avoided.